Blood Clots

Blood clots are life-threatening complications of COVID-19, and many doctors prescribe prophylactic anticoagulation drugs to prevent them. For some of his patients, Dr. Hooman Poor, pulmonologist at Mount Sinai Hospital, New York, uses tissue plasminogen activator (tPA).

Dr. Poor prescribed an injection of tPA to a 55 year old patient in shock and observed a good response. However, her condition deteriorated soon after, probably because of new clots forming. That said, Dr. Poor tried a low dose drip of tPA for 24 hours in addition to an anticoagulant. Unfortunately, the woman died from other complications days later.

This experimental treatment shows that research must be done to prevent and treat patients with blood clots.

Lauran Neergaard. Doctor treating COVID-19 patients gambles on clot-busting drug. April 11, 2020.

Original article: https://www.latimes.com/science/story/2020-04-11/doctor-treating-coronavirus-patients-gambles-on-clot-busting-drug

Deep vein thrombosis and pulmonary embolism have been described in many patients affected by COVID-19, including young adults without any risk factors. Many doctors have reported that the coagulation abnormalities were atypical, and that heparin wasn’t working in these patients.

In these situations, amputation may sometimes be the only way to treat ischemia. Also, artificial ventilation can be inefficient with pulmonary embolism because of the shunt created by the blood clots.

Ivan Couronne, Issam Ahmed. Blood Clots: Another Bad Surprise From COVID-19. La Presse. April 27, 2020.

Original article: https://www.lapresse.ca/covid-19/202004/27/01-5271122-une-autre-mauvaise-surprise-de-la-covid-19-des-caillots-de-sang.php

Different complications affecting multiple organs are being described with COVID-19. In fact, there is a higher risk of blood clotting when a patient has the virus. Other manifestations include arrhythmias, unsteady blood pressure, liver and kidney infections, and skin manifestations, especially on the fingers and toes. Also, severe cases can ultimately require ventilators, dialysis and even extracorporeal membrane oxygenation (ECMO), devices that can potentially cause infections.

Victoria Ahearn. Amputations, organ failure, blood clotting: The range of complications in COVID-19 cases. CTV News. April 22, 2020.

Original article: https://www.ctvnews.ca/health/coronavirus/amputations-organ-failure-blood-clotting-the-range-of-complications-in-covid-19-cases-1.4907290

Several cases of young COVID-19 patients diagnosed with strokes have been described, though they had a mild disease and no pre-existing health conditions. Dr. Thomas Oxley, a neurosurgeon at Mount Sinai Health System in New York, reported that the incidence of stroke in young individuals has increased sevenfold

Maggie Fox. COVID-19 causing blood clots, sudden strokes in young adults, doctors say. CTV News. April 24, 2020.

Original article: https://www.ctvnews.ca/health/coronavirus/covid-19-causing-blood-clots-sudden-strokes-in-young-adults-doctors-say-1.4910674