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home/Knowledge Base/Stages of COVID-19 Infection/Severe Infection

Thrombotic occlusive vasculopathy

25 views 0 05/25/2020 Audrey Mathieu

  1. Llamas-Velasco M. et al. described a 61-year-old male with ischemic digits and retiform purpura and livedoid lesions.
  • Nasopharyngeal swab was positive for SARS-CoV-2 infection.
  • The patient was admitted to the intensive care unit.
  • The lesions involve hands and feet.
  • Laboratory results revealed leucopenia, increased fibrinogen, increased D-dimer and a heterozygous Factor V Leiden mutation.
  1. Histopathological study show:
  • Sweat gland necrosis
  • Thrombi and fibrinoid necrosis in the upper dermis vessels and the dermo-hypodermal junction vessels
  1. The authors suggested that these lesions were related to an underlying systemic coagulopathy of COVID-19.

 

Source:

  1. Llamas-Velasco M., Munos-Hernandez P., Lazaro-Gonzalez J., et al. (May 14, 2020). Thrombotic occlusive vasculopathy in skin biopsy from a livedoid lesion of a COVID‐19 patient. British Journal of Dermatology. https://doi.org/10.1111/bjd.19222
Tags:PathologyAcrocyanosisPurpura and livedoid lesions

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