- The LYM% (blood lymphocyte percentage) can be used as a reliable indicator to classify the infection as moderate, severe and critical independently of any other auxiliary indicators.
- TML (Time-LYM%-model) is a tool of classification and prognosis prediction. TML-1 is defined as the LYM% at day 10-12 after symptom onset and TML-2 is the LYM% at day 17-19 after symptom onset.
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- TML-1: LYM% > 20 % are classified moderate and can recover quickly, otherwise it’s classified as severe and may need medical attention.
- TML-2: LYM% >20% are classified as in recovery, 5% < LYM% <20% are still in danger and need supervision, and LYM% <5% are critically ill with high mortality rate and need intensive care.
This figure was taken from https://www.nature.com/articles/s41392-020-0148-4#Fig1 and is published under an open access license.
The TML was created with the analysis of 12 random death cases, 7 random cases severe infection and 11 random cases of moderate infection. The TML was afterward validated using 90 hospitalized patients. All the patients come from China.
Source :
Tan L., Wang Q., Zhang D., et al. (March 27, 2020). Lymphopenia predicts disease severity of COVID-19: a descriptive and predictive study. Nature. https://doi.org/10.1038/s41392-020-0148-4