- AKI (acute kidney injury) is independently strongly associated with increased mortality and morbidity and is dependent on its severity (Stage 1 HR = 3.51, Stage 2 HR = 6.24, Stage 3 HR = 9.81)1
- CKD (chronic kidney disease) is associated with enhanced risk of severe COVID-19 infection (OR 3.03)2 and a greater in-hospital mortality (HR =2.99)1.
This data comes from two studies. Regarding the Cheng Y. et al. study, it is a prospective cohort study of 701 patients admitted with a confirmed COVID-19 infection in a tertiary teaching hospital in Wuhan, China. Pediatric patients and patients with a history of maintenance dialysis or renal transplantation were excluded from the study. Stages of AKI are defined according to the KDIGO criteria. As for the Brandon M.H et al study, it is a meta-analysis of 4 studies compiling 1389 COVID-19 patients with a clinically validated definition of severe disease. No adjustment for stages of CKD was performed.
- Cheng Y., Luo R., Wang K., Zhang M., Wang Z., Dong L., Li J., Yao Y., Ge S., Xu G. (March 20, 2020). Kidney disease is associated with in-hospital death of patients with COVID-19. Kidney International. https://doi.org/10.1016/j.kint.2020.03.005
- Brandon M.H., Giuseppe L. (March 11, 2020). Chronic kidney disease is associated with severe coronavirus disease 2019 (COVID-19) infection. International Urology and Nephrology (2020). https://doi.org/10.1007/s11255-020-02451-9