- Among COVID-19 related ARDS patients, low tidal volume (6.0 mL/kg) frequently induced hypercapnia.
- Ventilation Ratio is a simple bedside index of impaired efficiency of ventilation.
- Intermediate tidal volume (7-8 mL/kg predicted body weight) for COVID-19 related ARDS patients lowered Ventilation Ratio without a major impact on driving or plateau pressure.
This data come from an observational case series from China including 8 intubated patients with confirmed COVID-19 ARDS admitted to the Hospital of Guangzhou Medical University. They studied ventilation strategy for hypercapnic mechanically ventilated patients with COVID-19 ARDS.
Liu X., Liu X., Xu Y., et al ( March 23, 2020) Ventilatory Ratio in Hypercapnic Mechanically Ventilated Patients with COVID-19 Associated ARDS. AJRCCM. https://doi.org/10.1164/rccm.202002-0373LE