Public health

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Public health

Public health resources

13  articles in this collection
Written by Mathias Castonguay, Laurie-Anne Duquette, Noémie Desgagnés, Audrey Mathieu, 

Sleep Disturbance During the Confinement

1. Because of quarantine, sleep quality may be affected by major changes in routines (less physical activity, less exposure to daylight, homeworking and homeschooling), living with uncertainty (for example, about duration of the situation) and with insecurity (for example, about health and financial situation), social isolation and lack of rewarding activity. 2. Insomnia is a […]

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05/21/2020

Vaccine Development Landscape

This list shows candidate vaccines and their research stage on May 20th, 2020.  Candidate vaccines in clinical evaluation: 9 Vaccine  Platform Developer/ Location Stage Ad5-nCoV Non- Replicating Viral Vector CanSinoBiological Inc./ Beijing Institute of Biotechnology (China) Phase II ChiCTR2000031781  Phase I ChiCTR2000030906  mRNA-1273 RNA Moderna/NIAID (U.S.) Phase 2 (IND accepted) Phase 1 NCT04283461 ChAdOx1 nCoV-19 […]

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04/26/2020

Ethnic Minority

In the United States, African-American communities tend to have higher poverty rates, limited health care access and higher rates of jobs in service industries making it more difficult to work from home, with a subsequent increased exposure risk1 Infection rate is more than 3 times higher in predominantly African-American counties and death rate is 6-fold […]

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05/17/2020

Effects of Smoking

Key Points Smokers are more susceptible to the most recent species of Coronavirus infections3,5. History of smoking may also impact disease progression1,3. Smokers were 1.4 times more prone to develop severe symptoms1. They also had 2.4 times greater likelihood to be admitted to the ICU,  need mechanical ventilation or die1. Current  smokers have a significantly higher ACE-2 gene expression levels than non-smokers2,5,6. Suggesting an increased risk […]

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03/29/2020

Rationale Behind Coronaviruses’ Vaccines

What we know about SARS-CoV: Caused an outbreak in 2002; Immune responses are mediated by both humoral and cellular immunity; S protein is responsible for 3 important mechanisms:  attachment of the virus by binding to the ACE2; entry in the host cells and membrane fusion; allowing release of the viral RNA. This makes S protein the […]

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04/06/2020

Does Blood Type Matter?

There could be a potential increase in the risk of infection in patients with blood type A and, on the other hand, blood type O was associated with a potential lower susceptibility to SARS-CoV-2 ; The same patterns were identified in the dead patients, suggesting a higher mortality rate in type A and a decreased […]

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03/27/2020

Insights About Reinfection and Immunization

How long does the immunity last after infections with coronaviruses? Is it possible to get reinfected?  As of now, one of the hospital discharge criterias for COVID-19 infection is that with at least a one-day interval, two repetitive RT-PCR tests done on throat swabs have turned up negative. This method of testing is currently questioned […]

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05/02/2020

Anosmia as a Marker of Infection

Anosmia/hyposmia and ageusia are present in a majority of Covid-19 patients (5, 6) These symptoms are significantly more frequent in COVID-19 patients than influenza patients(1) and influenza-like patients. (6) They usually have an acute onset and commonly present as an initial manifestation. (1,5) Most patients reported complete or partial recovery of smell and taste. (1,6) […]

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03/26/2020

Dilemmas Regarding Oncology Care System

Delaying Treatment or Accepting Harm of Exposure? Many solid tumors (such as lung or pancreatic cancer) and some hematologic cancer (such as acute leukemia or aggressive lymphomas) require immediate diagnosis and treatment, opposed to other common early-stage cancers (breast, prostate, cervical, nonmelanoma skin…) that may not need immediate action and therefore prevent unnecessary exposition. For […]

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04/04/2020

How Immune Response to Previous Coronaviruses Pandemics May Help

Innate Immune Responses: Overall genomic similarity is observed between SARS-CoV2 and the 2 other viruses. Early elevation of pro-inflammatory cytokines were found in SARS-CoV2 infection but also in SARS-CoV and MERS-CoV pandemics. This suggests a potential similar cytokine storm-mediated disease. Type 1 interferon response is suppressed by both SARS-CoV and MERS-CoV viruses during infection by […]

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04/12/2020

Is a Symptom-Based Screening Process Effective?

A symptom-based and epidemiology-based screening process was ineffective in detecting all SARS-CoV-2 cases. Persons who have no fever and no signs or symptoms of respiratory infection can potentially shed SARS-CoV-2. The proportion of asymptomatic cases among individuals who tested positive for SARS-CoV-2 is around 17.9%. Since the viral loads between asymptomatic and symptomatic patients are […]

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04/04/2020

What Is the Efficacy of Masks in Preventing Transmission?

Aerosol is a potential mode of transmission from asymptomatic individuals. Surgical masks could reduce the emission of virus particles into the environment in droplets and aerosols. Therefore, they have the potential to reduce onward transmission if worn by symptomatic individuals. Only a minority (35%) of infected participants shed detectable virus in droplets or aerosols, and […]

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04/10/2020

Singapore Flattening the Curve

Every patient with a confirmed or suspected diagnosis of COVID-19 were isolated in hospital. Aggressive contact tracing was then initiated to determine possible sources of infection and to prevent onward transmission. Close contacts of confirmed or suspected case were placed under mandatory quarantine for 14 days; economic assistance was provided and those who do not comply […]

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04/04/2020