Other Internal Medicine Specialties

null

null

null

null

null

null

Other Internal Medicine Specialties

Resources on other internal medicine specialties

8  articles in this collection
Written by Mathias Castonguay, Philippe Mercier, Vanessa Perto, David Khalil, 

Is Testosterone a Good or a Bad Guy?

Worldwide epidemiology studies have found higher number of cases of SARS-CoV-2 in men. Moreover, male gender carries a worse prognosis, especially in younger adults. Two opposing theories about androgens have been proposed to explain the gender gap. Testosterone as a promoter of COVID-19 infection: Transmembrane protease serine 2 (TMPRSS2) is a cellular co-receptor required for […]

Written by
05/11/2020

Considerations in the Management of Diabetes in the Pandemic Context

Diabetes is an important risk factor for poorer outcomes in COVID-19. Mechanistic hypotheses include the effect of acute and chronic hyperglycemia on angiotensin-converting-enzyme-2 receptor, impaired immune response and confounding population characteristics such as age and cardiovascular comorbidities. Prevention: Patients at risk of metabolic disease who have contracted the infection should be monitored to prevent new […]

Written by
05/04/2020

Should We Discontinue ACE-I and ARB?

Despite some evidence of up-regulation of ACE2 by RAAS inhibition, with its theoretically associated higher susceptibility to COVID-19 infection and increased viral load, there is currently no data suggesting a causal relationship between ACE2 activity and COVID-19 associated mortality; therefore, based on currently available data, the assumption of a causal relationship between ACE-I or ARB […]

Written by
04/03/2020

A Case of Immune Thrombocytopenic Purpura (ITP)

COVID-19 may potentially represent a novel etiology for ITP, although we cannot exclude other causes of thrombocytopenia in this case (e.g. thrombocytopenia related to amoxicillin–clavulanic acid exposure).   A 65-year-old woman with hypertension and autoimmune hypothyroidism was admitted with COVID-19 pneumonia in Strasbourg, France. Laboratory tests performed at admission showed a normal full blood count […]

Written by
04/27/2020

Risk of Severe Presentation in Lupus Patients

Systemic lupus erythematosus is a probable risk factor to SARS-CoV-2 infection and severe COVID-19 presentation, independent of the immunosuppressive state from lupus therapy. In lupus patients, epigenetic dysregulation enhances viral entry into cells and induces pro-inflammatory changes resulting in a vicious cycle of cytokine response, and an increased possibility of cytokine storm. SARS-CoV-2 uses angiotensin-converting […]

Written by
05/03/2020

Kidney Function and Mortality

AKI (acute kidney injury) is independently strongly associated with increased mortality and morbidity and is dependent on its severity (Stage 1 HR = 3.51, Stage 2 HR = 6.24, Stage 3 HR = 9.81)1 CKD (chronic kidney disease) is associated with enhanced risk of severe COVID-19 infection (OR 3.03)2 and a greater in-hospital mortality (HR […]

Written by
04/01/2020

Understanding and Managing Kidney Injury

Kidney injury in COVID-19 infection may results from two different mechanisms: Hypoperfusion of the renal tubules secondary to the cytokine storm and shock.1,2 Direct cytopathogenic effect of SARS-CoV-2. Reports suggest that ACE2 (essential for virus uptake by cells) is highly expressed on podocytes and renal tubular epithelial cells (RTEC). Hematuria and albuminuria along with viral […]

Written by
04/12/2020

Prevention of Transmission in Haemodialysis Centres

Recommendations for the health care team include:– training to the use of personal protective equipment (N95 mask, goggles, mobcap, disposable surgical blouse and gloves) when caring for confirmed cases;– self-monitoring symptoms and inform team leader if suspicion of symptoms or contact with confirmed case; stay home if unwell. Recommendations for dialysis patients consist of:– appropriate […]

Written by
04/08/2020