Neurology

null

null

null

null

null

null

Neurology

Resources for managing neurology patients

8  articles in this collection
Written by Anne-Marie Lavigne, Philippe Mercier, Cindy Nguyen, 

Management of Migraine

COVID-19 pandemic causes change in daily routine, increases anxiety and brings other stressors that could trigger or worsen headaches. Headache has been described as an early symptom of COVID-19. Clinicians should review other symptoms and exposure risk for patients with new onset of severe headache or a worsening one. Minimize visits and procedural treatments. Telemedicine […]

Written by
04/17/2020

Association with Guillain-Barré Syndrome

Guillain-Barré syndrome has previously been reported in human coronavirus infections.1 A first presumed case of acute Guillain-Barré syndrome “parainfectious” to COVID-19 was described in a 61-year-old woman who initially presented with lower-limb weakness. She developed respiratory symptoms eight days later and was tested positive for SARS-CoV-2 on RT-PCR assay.2 Later, other cases of post-infectious Guillain-Barré syndrome […]

Written by
04/12/2020

Neuroinvasive Potential of COVID-19

Previous studies have shown that CoVs, like SARS-CoV, have a tropism for the central nervous system. Due to its high similarity with SARS-CoV,  SARS-CoV-2 may also possess a similar neuroinvasive potential, which may partially explain the acute respiratory failure of COVID-19 patients. Review of past studies on coronaviruses’s propensity for neuroinvasion.   Source:  Li YC, […]

Written by
03/28/2020

Neurologic Manifestations in Severely Ill Patients

36.4% of patients had neurological symptoms, most frequently headache, dizziness and impaired consciousness. About 5% of patients reported either hypogeusia or hyposmia. Severely ill patients were more likely to develop acute cerebrovascular diseases, impaired consciousness and skeletal muscle injury.   This data comes from a non-peer reviewed retrospective case series conducted in three hospitals of […]

Written by
04/19/2020

Neuro-Oncologic Disease: Management Suggestions

Regarding surveillance and follow-up: Telemedicine appointments should replace routine in-clinic visits whenever possible. Outpatient radiology should remain accessible for patients and providers; radiology departments must establish protocols to limit risk of viral exposure for patients and staff. Regarding treatment and procedures: Consider whether treatment can be reasonably postponed until recovery; if it cannot, appropriate management […]

Written by
04/27/2020

A First Presumptive Case Report of Acute Necrotizing Hemorrhagic Encephalopathy

Acute necrotizing encephalopathy (ANE) is a rare complication of influenza and other viral infections and has been related to intracranial cytokine storms. A female airline worker in her late fifties is the first reported case of acute necrotizing hemorrhagic encephalopathy associated with SARS-CoV-2. Hemorrhagic bithalamic lesions were demonstrated by CT and MRI imagery. However, detection […]

Written by
04/17/2020

Association between Human Coronaviruses and Neurological Disorders

Human CoV (HCoV) presence in the human CNS has been reported. Neurological disorders (i.e. meningitis, encephalitis, acute flaccid paralysis, Guillain-Barré syndrome and ADEM) have been associated with HCoV infections. Long-term neurological sequelae may be present if HCoV persist in resident cells of the CNS. It could lead to the development or aggravation of chronic neurological […]

Written by
04/08/2020

Potential Mechanism of Dissemination in the CNS

SARS-CoV-2, similarly to SARS-CoV-1 , uses the angiotensin-converting enzyme 2 (ACE2) receptor to enter cells. ACE 2 receptors are present in glial cells and neurons. The spike protein of SARS-CoV-2 that binds the virion to the cell membrane using host ACE2 receptors has a higher affinity than SARS-CoV 1 spike protein. SARS-CoV-2 could disseminate through […]

Written by
04/10/2020