- Human CoV (HCoV) presence in the human CNS has been reported.
- Neurological disorders (i.e. meningitis, encephalitis, acute flaccid paralysis, Guillain-Barré syndrome and ADEM) have been associated with HCoV infections.
- Long-term neurological sequelae may be present if HCoV persist in resident cells of the CNS. It could lead to the development or aggravation of chronic neurological diseases.
This data comes from a review of over 300 studies on coronaviruses and other respiratory viruses effect on human and animals such as monkeys and mice.
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Desforges M., Le Coupanec A. and al. (December 20, 2019) Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?. MDPI https://doi.org/10.3390/v12010014
Kim J.E., Heo J.H. and al. (July, 2017). Neurological complications during Treatment of Middle East Respiratory Syndrome. Journal of Clinical Neurology. https://doi.org/10.3988/jcn.2017.13.3.227
Wu Y., Xu X. and al. (Accepted March 28, 2020). Nervous System Involvement after Infection with COVID-19 and Other Coronaviruses. Brain, Behavior, and Immunity (2020).https://doi.org/10.1016/j.bbi.2020.03.031
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