- The United States (including New York City) and the United Kingdom have recently reported cases of multi-system inflammatory syndrome in children and adolescents potentially associated with COVID-19.
- The NYC Health Department reported 15 patients hospitalized between April 17 and May 1 with symptoms consistent with this syndrome.
- The presentation varies between a typical Kawasaki disease, an incomplete Kawasaki disease and/or a toxic shock syndrome-like.
- Patients were between 2 and 15 years old.
- All patients had suspected or confirmed fever. More than half had rashes, abdominal pain or vomiting and less than half had respiratory symptoms.
- Many required cardiac or respiratory support.
- The PCR was positive for 4 patients and negative for 10 patients, 6 of whom were serologically positive.
- A child presenting in toxic shock or with symptoms of atypical Kawasaki disease should alert pediatricians of possible severe SARS-CoV-2 infection. Suspected cases should be referred to a specialist in pediatric infectious disease, rheumatology, and/or critical care. However, severe cases remain rare in the pediatric population.
This data come from 3 sources. Paediatric Intensive Care Society conducted a study describing a case of concomitant COVID-19 infection and Kawasaki Disease. The patient was a 6-month-old female who was admitted for classic Kawasaki Disease and was also tested positive for SARS-CoV-2. She was treated according to the Kawasaki’s treatment guidelines. Schillinger J. presented a health alert from NYC Health Department on pediatric multi-system inflammatory syndrome. Herman A. O. reported the latest news about the pediatric multi-system inflammatory syndrome.
- Herman A. O. (May 6, 2020) COVID-19: Multisystem Inflammatory Syndrome / Risk Factors & Distress in Healthcare Workers / Llama Antibodies. NEJM Journal Watch. https://doi.org/10.1056/nejm-jw.FW116617
- Jones VG, Mills M, Suarez D, et al. COVID-19 and Kawasaki disease: novel virus and novel case. Hosp Pediatr. 2020; doi: 10.1542/hpeds.2020-0123 https://hosppeds.aappublications.org/content/early/2020/04/06/hpeds.2020-0123.long
- Paediatric Intensive Care Society. PICS statement regarding novel presentation of multi-system inflammatory disease. 27th April 2020. https://picsociety.uk/wp-content/uploads/2020/04/PICS-statement-re-novel-KD-C19-presentation-v2-27042020.pdf
- Schillinger J. (May 4, 2020). Pediatric Multi-System Inflammatory Syndrome Potentially Associated with COVID-19. Retrieved from : https://www1.nyc.gov/assets/doh/downloads/pdf/han/alert/2020/covid-19-pediatric-multi-system-inflammatory-syndrome.pdf