Blood clots are life-threatening complications of COVID-19, and many doctors prescribe prophylactic anticoagulation drugs to prevent them. For some of his patients, Dr. Hooman Poor, pulmonologist at Mount Sinai Hospital, New York, uses tissue plasminogen activator (tPA).
Dr. Poor prescribed an injection of tPA to a 55 year old patient in shock and observed a good response. However, her condition deteriorated soon after, probably because of new clots forming. That said, Dr. Poor tried a low dose drip of tPA for 24 hours in addition to an anticoagulant. Unfortunately, the woman died from other complications days later.
This experimental treatment shows that research must be done to prevent and treat patients with blood clots.
Lauran Neergaard. Doctor treating COVID-19 patients gambles on clot-busting drug. April 11, 2020.